I'm not so sure, the answer to the big question (the question about life, the universe, and everything) really is 42. Think about it... To how many questions can you actually answer "42"? And to how many questions can you answer "because, fuck it"?
And after we realize that, we can also come to terms with the fact that we already know the question; "Why did the chicken cross the road?". Obviously, the answer "42" makes no sense at all, but then try with "because, fuck it!". See, not only do we now know the true answer to the big question, but we also know the question itself!